Depression

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Causes and Risk Factors

The cause of major depressive disorder is a combination of brain chemistry, family history, and psychosocial environment. It is not certain which of these factors dominates, but abnormal levels of the neurotransmitters norepinephrine, serotonin, and dopamine are closely linked with depression. Thus, the cause of depression is often attributed to a "chemical imbalance." These neurotransmitters play important roles in how we experience pleasure and moods.




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